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Malarone tablets malaria prophylaxis

Malarone (Proguanil / Atovaquone) 100 mg / 250mg Tab Pack of 12 tabs

Original price was: £35.90.Current price is: £33.50.

Malarone Tablets

What Malarone Tablets is and what it is used for

Malarone (Proguanil / Atovaquone) tablets belong to a group of medicines called antimalarials. It contains two active ingredients, atovaquone, and proguanil hydrochloride. Each Malarone tablet contains 250 mg atovaquone and 100 mg proguanil hydrochloride.

Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite (Plasmodium falciparum) into the bloodstream. Proguanil / Atovaquone tablets prevent malaria by killing this parasite. For people who are already infected with malaria, Proguanil / Atovaquone tablets also kills these parasites.

What Malarone tablets is used for

Malarone has two uses:

  • to prevent malaria
  • to treat malaria

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How To Prevent Malaria

 

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Description

Malarone (Proguanil / Atovaquone) 100 mg / 250mg Tab Pack of 12 tabs

Malarone active ingredients is a fixed-dose combination of atovaquone and proguanil hydrochloride and is used for Prophylaxis of malaria. and the Treatment of acute, uncomplicated malaria.

How To use

How to Take Malarone

Take Malarone with food or a milky drink, where possible.

It is best to take Malarone at the same time each day.

If you are sick (vomit)

For preventing malaria:

  • if you are sick(vomit)within 1 hour of taking your Malarone tablet, take another dose straight away
  • it is important to take the full course of Malarone. If you have to take extra tablets due to sickness, you may need another prescription.
  • if you have been vomiting, it is especially important to use extra protection, such as repellents and bednets. Malarone may not be as effective, as the amount absorbed will be reduced.

For treating malaria:

  • if you have vomiting and diarrhoea tell your doctor, you will need regular blood tests. Malarone will not be as effective, as the amount absorbed will be reduced. The tests will check whether the malaria parasite is being cleared from your blood.

To prevent malaria

The recommended usual dose for adults is 1 tablet once a day, taken as below.

Not recommended for preventing malaria in children, or in adults who weigh less than 40 kgs.

Malarone paediatric tablets are recommended for preventing malaria in adults and children who weigh less than 40 kgs.

To prevent malaria in adults:

  • start taking Malarone 1 to 2 days before travelling to an area which has malaria
  • continue taking it every day during your stay
  • continue taking it for another 7 days after your return to a malaria-free area.

To treat malaria

The recommended dose for adults is 4 tablets once a day for 3 days.

For children the dose depends on their bodyweight:

  • 11-20 kg – 1 tablet once a day for 3 days
  • 21-30 kg – 2 tablets once a day for 3 days
  • 31-40 kg – 3 tablets once a day for 3 days
  • over 40 kg – dose as for adults.

Not recommended for treating malaria in children who weigh less than 11 kgs.

For children who weigh less than 11 kgs talk to your doctor. There may be a different type of Malarone tablet available in your country.

If you take more Malarone than you should

Contact a doctor or pharmacist for advice. If possible show them the Malarone pack.

If you forget to take Malarone

It is very important that you take the full course of Malarone.

If you forget to take a dose, don’t worry. Just take your next dose as soon as you remember. Then continue your treatment as before.

Don’t take extra tablets to make up for a missed dose. Just take your next dose at the usual time.

Don’t stop taking Malarone without advice

Keep taking Malarone for 7 days after you return to a malaria-free area. Take the full course of Malarone for maximum protection. Stopping early puts you at risk of getting malaria, as it takes 7 days to ensure that any parasites that may be in your blood following a bite from an infected mosquito are killed.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Patient Information Leaflet

Warnings

Do not take Malarone:

  • if you are allergic to atovaquone, proguanil hydrochloride or any of the ingredients of this medicine listed in section 6.
  • for preventing malaria, if you have severe kidney disease.
  • Tell your doctor if either of these apply to you.

Take special care with Malarone

Talk to your doctor or pharmacist before taking Malarone if:

  • you have severe kidney disease
  • your child is being treated for Malaria and weighs less than 11 kg. There is another tablet strength to treat children who weigh less than 11 kg (see section 3).
  • Tell your doctor or pharmacist if any of these applies to you.

Other medicines and Malarone

Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines you’ve bought without a prescription.

Some medicines can affect the way Malarone works, or Malarone itself can strengthen or weaken the effectiveness of other medicines taken at the same time. These include:

  • metoclopramide, used to treat nausea and vomiting
  • the antibiotics, tetracycline, rifampicin and rifabutin
  • efavirenz or certain highly active protease-inhibitors used to treat HIV
  • warfarin and other medicines that stop blood clotting
  • etoposide used to treat cancer.
  • Tell your doctor if you are taking any of these. Your doctor may decide that Malarone isn’t suitable for you, or that you need extra check ups while you’re taking it.
  • Remember to tell your doctor if you start taking any other medicines while you’re taking Malarone.

Malarone with food and drink

Take Malarone with food or a milky drink, where possible. This will increase the amount of Malarone your body can absorb, and make your treatment more effective.

Pregnancy and breast-feeding

If you are pregnant, do not take Malarone unless your doctor recommends it.

  • Ask your doctor or pharmacist for advice before taking Malarone

Do not breast-feed while taking Malarone, as the ingredients of Malarone may pass into breast milk and may harm your baby.

Driving and using machines

If you feel dizzy, do not drive.

Malarone makes some people feel dizzy. If this happens to you, do not drive, use machines or take part in activities where you may put yourself or others at risk.

Side Effects

Malarone Side Effects

Like all medicines, this Malarone can cause side effects, although not everybody gets them.

Look out for the following severe reactions. They have occurred in a small number of people, but their exact frequency is unknown.

Severe allergic reactions – signs include:

  • rash and itching
  • sudden wheezing, tightness of the chest or throat, or difficulty breathing
  • swollen eyelids, face, lips, tongue or other part of the body.
  • Contact a doctor immediately if you get any of these symptoms. Stop taking Malarone.

Severe skin reactions

  • skin rash, which may blister and looks like small targets (central dark spots, surrounded by paler area with a dark ring around the edge) (erythema multiforme)
  • severe widespread rash with blisters and peeling skin, particularly occurring around the mouth, nose, eyes and genitals (Stevens-Johnson syndrome).
  • If you notice any of these symptoms contact a doctor urgently.

Most of the other side effects reported have been mild and have not lasted very long.

Very common side effects of Malarone

These may affect more than 1 in 10 people:

  • headache
  • feeling sick and being sick (nausea and vomiting)
  • stomach pain
  • diarrhoea.

Common Malarone side effects 

These may affect up to 1 in 10 people:

  • dizziness
  • sleeping problems (insomnia)
  • strange dreams
  • depression
  • loss of appetite
  • fever
  • rash which may be itchy
  • cough

Common side effects, which may show up in your blood tests are:

  • reduced numbers of red blood cells (anaemia) which can cause tiredness, headaches and shortness of breath
  • reduced numbers of white blood cells (neutropenia) which may make you more likely to catch infections
  • low levels of sodium in the blood (hyponatraemia)
  • an increase in liver enzymes.

Uncommon side effects

These may affect up to 1 in 100 people:

  • anxiety
  • an unusual awareness of abnormal beating of the heart (palpitations)
  • swelling and redness of the mouth
  • hair loss
  • itchy, bumpy rash (hives).

Uncommon side effects that may show up in your blood tests:

  • an increase in amylase (an enzyme produced in the pancreas).

Rare side effects

These may affect up to 1 in 1,000 people:

  • seeing or hearing things that are not there (hallucinations)

Other side effects

Other side effects have occurred in a small number of people but their exact frequency is unknown.

  • Inflammation of the liver(hepatitis)
  • blockage of the bile ducts (cholestatis)
  • increase in heart rate (tachycardia)
  • inflammation of the blood vessels (vasculitis) which may be visible as red or purple raised spots on the skin but can affect other parts of the body
  • fits (seizures)
  • panic attacks, crying
  • nightmares
  • severe mental health problem in which the person loses contact with reality and is unable to think and judge clearly
  • indigestion
  • mouth ulcers
  • blisters
  • peeling skin
  • increased sensitivity of the skin to sunlight.

Other side effects that may show up in your blood tests:

  • A decrease in all types of blood cells (pancytopenia).

Reporting of side effects

If you get any side effects talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard.

By reporting side effects you can help provide more information on the safety of this medicine.

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